Business analytics in industry 4.0: a systematic review

Recently, the term “Industry 4.0” has emerged to characterize several Information Technology and Communication (ICT) adoptions in production processes (e.g., Internet-of-Things, implementation of digital production support information technologies). Business Analytics is often used within the Industry 4.0, thus incorporating its data intelligence (e.g., statistical analysis, predictive modelling, optimization) expert system component. In this paper, we perform a Systematic Literature Review (SLR) on the usage of Business Analytics within the Industry 4.0 concept, covering a selection of 169 papers obtained from six major scientific publication sources from 2010 to March 2020. The selected papers were first classified in three major types, namely, Practical Application, Reviews and Framework Proposal. Then, we analysed with more detail the practical application studies which were further divided into three main categories of the Gartner analytical maturity model, Descriptive Analytics, Predictive Analytics and Prescriptive Analytics. In particular, we characterized the distinct analytics studies in terms of the industry application and data context used, impact (in terms of their Technology Readiness Level) and selected data modelling method. Our SLR analysis provides a mapping of how data-based Industry 4.0 expert systems are currently used, disclosing also research gaps and future research opportunities.The work of P. Cortez was supported by FCT - Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: UIDB/00319/2020. We would like to thank to the three anonymous reviewers for their helpful suggestions

Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension

Tobacco, alcohol, and marijuana consumption is an important public health problem because of their high use worldwide and their association with the risk of mortality and many health conditions, such as hypertension, which is the commonest risk factor for death throughout the world. A likely pathway of action of substance consumption leading to persistent hypertension is DNA methylation. Here, we evaluated the effects of tobacco, alcohol, and marijuana on DNA methylation in the same cohort (N = 3,424). Three epigenome-wide association studies (EWAS) were assessed in whole blood using the InfiniumHumanMethylationEPIC BeadChip. We also evaluated the mediation of the top CpG sites in the association between substance consumption and hypertension. Our analyses showed 2,569 CpG sites differentially methylated by alcohol drinking and 528 by tobacco smoking. We did not find significant associations with marijuana consumption after correcting for multiple comparisons. We found 61 genes overlapping between alcohol and tobacco that were enriched in biological processes involved in the nervous and cardiovascular systems. In the mediation analysis, we found 66 CpG sites that significantly mediated the effect of alcohol consumption on hypertension. The top alcohol-related CpG site (cg06690548, P-value = 5.9·10−83) mapped to SLC7A11 strongly mediated 70.5% of the effect of alcohol consumption on hypertension (P-value = 0.006). Our findings suggest that DNA methylation should be considered for new targets in hypertension prevention and management, particularly concerning alcohol consumption. Our data also encourage further research into the use of methylation in blood to study the neurological and cardiovascular effects of substance consumption

Structure, morphology and optical characterization of Dy3+-doped BaYF5 nanocrystals for warm white light emitting devices

The barium yttrium fluoride BaYF5 nanocrystalline powders doped with different concentrations of Dy3+ ions have been synthesized via a hydrothermal method and studied their structural, morphological, thermal, vibrational, and optical properties. These nanopowders have been crystallized in a single phase of the tetragonal structure with the average size of around 30 nm having spherical shape in morphology. Upon excitations at 350 and 387 nm, Dy3+ -doped BaYF5 nanocrystals exhibit strong blue and yellow emissions ascribed to the F-4(9/2) -> H-6(15/2) and F-4(9/2) -> H-6(13/2) transitions, respectively. Decay curves of the F-4(9/2) level of Dy3+ ion in BaYF5 nanocrystals exhibit non-exponential nature due to the dipole-dipole interaction between Dy3+ ions, confirmed by Inokuti-Hirayama model. The quantum yield for these nanocrystals have been found to be increased from 4.64% to 11.61% as the concentration of Dy3+ ions increases from 1.0 mol% to 2.0 mol% and then decreased to 10.68% as the dopant concentration increased to 5.0 mol%. Moreover, color coordinates and correlated color temperatures have been evaluated as a function of concentration and excitation wavelength and found to be in the warm white light region for all Dy3+ concentrations

Structure, morphology and optical characterization of Dy3+-doped BaYF5 nanocrystals for warm white light emitting devices

The barium yttrium fluoride BaYF5 nanocrystalline powders doped with different concentrations of Dy3+ ions have been synthesized via a hydrothermal method and studied their structural, morphological, thermal, vibrational, and optical properties. These nanopowders have been crystallized in a single phase of the tetragonal structure with the average size of around 30 nm having spherical shape in morphology. Upon excitations at 350 and 387 nm, Dy3+ -doped BaYF5 nanocrystals exhibit strong blue and yellow emissions ascribed to the F-4(9/2) -> H-6(15/2) and F-4(9/2) -> H-6(13/2) transitions, respectively. Decay curves of the F-4(9/2) level of Dy3+ ion in BaYF5 nanocrystals exhibit non-exponential nature due to the dipole-dipole interaction between Dy3+ ions, confirmed by Inokuti-Hirayama model. The quantum yield for these nanocrystals have been found to be increased from 4.64% to 11.61% as the concentration of Dy3+ ions increases from 1.0 mol% to 2.0 mol% and then decreased to 10.68% as the dopant concentration increased to 5.0 mol%. Moreover, color coordinates and correlated color temperatures have been evaluated as a function of concentration and excitation wavelength and found to be in the warm white light region for all Dy3+ concentrations

Skeletal Muscle DNA Methylation and mRNA Responses to a Bout of Higher versus Lower Load Resistance Exercise in Previously Trained Men

We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA responses to one bout of lower load (LL) versus higher load (HL) resistance exercise. Trained college-aged males (n = 11, 23 ± 4 years old, 4 ± 3 years self-reported training) performed LL or HL bouts to failure separated by one week. The HL bout (i.e., 80 Fail) consisted of four sets of back squats and four sets of leg extensions to failure using 80% of participants estimated one-repetition maximum (i.e., est. 1-RM). The LL bout (i.e., 30 Fail) implemented the same paradigm with 30% of est. 1-RM. Vastus lateralis muscle biopsies were collected before, 3 h, and 6 h after each bout. Muscle DNA and RNA were batch-isolated and analyzed using the 850k Illumina MethylationEPIC array and Clariom S mRNA microarray, respectively. Performed repetitions were significantly greater during the 30 Fail versus 80 Fail (p p = 0.571). Regardless of bout, more CpG site methylation changes were observed at 3 h versus 6 h post exercise (239,951 versus 12,419, respectively; p < 0.01), and nuclear global ten-eleven translocation (TET) activity, but not global DNA methyltransferase activity, increased 3 h and 6 h following exercise regardless of bout. The percentage of genes significantly altered at the mRNA level that demonstrated opposite DNA methylation patterns was greater 3 h versus 6 h following exercise (~75% versus ~15%, respectively). Moreover, high percentages of genes that were up- or downregulated 6 h following exercise also demonstrated significantly inversed DNA methylation patterns across one or more CpG sites 3 h following exercise (65% and 82%, respectively). While 30 Fail decreased DNA methylation across various promoter regions versus 80 Fail, transcriptome-wide mRNA and bioinformatics indicated that gene expression signatures were largely similar between bouts. Bioinformatics overlay of DNA methylation and mRNA expression data indicated that genes related to “Focal adhesion,” “MAPK signaling,” and “PI3K-Akt signaling” were significantly affected at the 3 h and 6 h time points, and again this was regardless of bout. In conclusion, extensive molecular profiling suggests that post-exercise alterations in the skeletal muscle DNA methylome and mRNA transcriptome elicited by LL and HL training bouts to failure are largely similar, and this could be related to equal volumes performed between bouts